HNE-34806 Nutritional Genomics and Genetics
Course
Credits 6.00
| Teaching method | Contact hours |
| Lectures | 20 |
| Practical extensively supervised | 9 |
| Practical intensively supervised | 18 |
| Problem-based learning | 12 |
| Tutorial | 9 |
| Self-study |
| Course coordinator(s) | prof. dr. MR Müller |
| Lecturer(s) | prof. dr. MR Müller |
| dr. ir. GJEJ Hooiveld | |
| prof. dr. ir. AH Kersten | |
| prof. dr. ir. E Kampman | |
| prof. dr. EG Schouten | |
| prof. dr. ir. J Keijer | |
| dr. B. van Ommen | |
| Examiner(s) | prof. dr. MR Müller |
Language of instruction:
English
Assumed knowledge on:
HNE-34306 Advanced Metabolic Aspects of Nutrition; MIB-10306 Celb Biology 2
Continuation courses:
Thesis Metabolism and Nutrigenomics
Contents:
See website (http://nutrigene.4t.com/molnut3.htm) for more information.
Aims:
- understand the basics of genetics, genomics and gene regulation with relation to diet;
- be able to read and understand literature of the field;
- have good understanding of the concepts of molecular nutrition research (signals and signaling pathways, dietary sensors (nuclear receptors), organ sensing, use of models);
- have some understanding of the concepts of nutrigenetics (genetic susceptibility, SNPs, polygenic (complex) diseases, "personalized" diet);
- have good understanding of the concepts of nutrigenomics (dietary signatures, identification of very early biomarkers, "Two Hits");
- have some (practical) knowledge to apply molecular nutrition and nutrigenomics in the lab (use of transgenic animals and cells, RNAi, infection with recombinant adenoviral constructs, laser capture microdissection, Real time-PCR, microarrays, bioinformatics);
- be able to extract relevant data/information from internet for molecular nutrition research (data mining).
Activities:
To reach these objectives, the student will:
- prepare and follow lectures;
- search and read relevant original research papers, and prepare a presentation;
- participate in a lab course on genetics and genomics, and write a report.
Examination:
- written examination (individual);
- performance during presentation (individual).
Literature:
- Syllabus (handouts will be sold during the course and they will available on Blackboard; additional resources such as research papers etc are on the Blackboard site);
- Stipanuk: Biochemical and Physiological Aspects of Human Nutrition (not necessary but recommended);
- Campbell & Heyer: Discovering Genomics, Proteomics & Bioinformatics or comparable books (not necessary but recommended).