CBI-50806 Immunomodulation by Food and Feed

Course

Credits 6.00

Language of instruction:

English

Assumed knowledge on:

CBI-10306 Cell Biology; MIB-11306 Microbiology and Biochemistry for Nutrition and Health.

Continuation courses:

CBI-20306 Cell Biology and Health; MIB-30806 Applied Molecular Microbiology.

Contents:

The immune system plays a pivotal part in the maintenance of human and animal health and well-being. Disturbances may lead to over-activity against self-antigens (resulting in auto-immunity), over-activity against harmless environmental antigens (causing allergies), or immune suppression (with impaired resistance against infections and the development of tumors). Immunomodulation offers options to redirect and rebalance the perturbed immune system via food and feed and components that are derived thereof. The interactions between the immune system and food components, food-borne infections and gut microbiota are the central items of this course. The course comprises an overview of underlying mechanisms of immune-related disorders related to disturbed balances in (gut) microbiota and in interaction with selected food components in humans, companion and production animals.

Learning outcomes:

At the end of the course the student is expected to be able to demonstrate a detailed understanding:
- of the concept of immunomodulation and its application in the modification and re-directioning of immune-mediated diseases;
- of selected food components with defined immunological activity, the mechanisms of action of such compounds, and the tools that are necessary and widely used to assess this activity;
At the end of the course the student is expected able:
- to define and memorize the impact of food components on structure-activity relationship of the gut-associated immune system and the gut microbiota;
- to design a systems biological approach for the multiparameter and multilevel analysis of the immunomodulatory effect of (selected) food components on cytokine networks and resulting T-cell mediated activity

Activities:

Attend lectures that are supported by handout lecture material, attend working groups and self-study based on problem oriented education using selected relevant papers. A practical will deal with the tools commonly used to assess the modulatory activity of food components on the immune and microbiota activity.

Examination:

The synthesis of the different aspects of interactions between food components and food-borne infections with immune functioning and structure-function relationships of the gut microbiota will be assessed in a written exam using assay questions (50%). A separate mark will be given for the practical (20%), and also a separate mark will be given for the individual case study report (30%).

Literature:

Study guide, reader, selected literature, practical manual.