BIP-31806 Advances in Magnetic Resonance

Course

Credits 6.00

Language of instruction:

English

Assumed knowledge on:

BIP-31306 Spectroscopy.

Contents:

The development of molecular sciences for materials, food and health critically depends on comprehensive and non-invasive product characterization. Nuclear magnetic resonance (NMR) is probably the most widely applied analytical method with applications in e.g. analytical chemistry (identification and molecular structure), structural biology (structure, functional dynamics and interactions of large biomolecules; proteomics), solid materials (physical characterization), imaging (visualization and functional analysis of tissues, organs and organisms of humans, animals and plants), metabolomics (quantitative analysis of metabolites), transport processes (characterization of transport in porous (bio)materials with applications in diverse fields like chemical engineering, medicine, food technology, geophysics, biology and ecology).
NMR can be considered special because fundamentally novel scientific discoveries in NMR and MRI have consistently emerged with the development of science. In this course a generalized formalism will be introduced to analyze and understand diverse classes of modern NMR and MRI experiments. The course material will be exemplified by using practical examples of both NMR and MRI from the field of molecular life sciences.

Learning outcomes:

At the end of the course, the student is expected to be able to:
- perform calculations with spin systems, spin operators, field gradients and coherence transfer pathways;
- understand divers modern NMR and MRI experiments;
- understand the effects of relaxation, flow, molecular diffusion, chemical shift and spin-spin couplings;
- demonstrate the use of advanced magnetic resonance methods in practical situations;
- apply magnetic resonance methods to biomolecules and biological systems.

Activities:

- attend lectures and studying the course material;
- working out of problems and exercises;
- performing magnetic resonance experiments in small groups;
- analysis of experimental results;
- use ICT for analysis and simulations;
- study of cases;
- writing reports.

Examination:

The course will be concluded with a written exam. The required course material for this exam consists of the course materials treated in all lectures, tutorials, and laboratory experiments. The exam has an open-book character and consists of a number of open problems. The laboratory experiments are evaluated on basis of: presence, knowledge, experimental results, working out of the exercises and reports. The final mark is calculated as follows: 70% written exam, 30% laboratory experiments. The bottom mark for both parts is a 5. The final mark can be assessed only after completing all practical courses. Partial results remain valid for a period of 5 years.

Literature:

A syllabus and manual for practical experiments will be available at the beginning of the course.