ABG-30306 Genomics

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Studiepunten 6.00

Language of instruction:

English

Assumed knowledge on:

Basic knowledge molecular biology and genetics, such as given in the courses BIC10306, MOB20306 and GEN10306

Contents:

The course discusses the structure and function of genomes of living organisms from all kingdoms. The topics that are treated cover: - molecular markers;
- linkage maps;
- fluorescent in situ hybridization;
- chromosome structure and topology;
- whole genome sequence analysis;
- whole genome comparison;
- genome synteny and evolution;
- expression analysis by micro-array techniques;
- proteomics;
- functional genome analysis by random and targeted mutagenesis.

Aims:

The participants should acquire knowledge about: - methods to study genome structures of organisms from various kingdoms;
- correlation between genetic and genomic information;
- the organisation of prokaryotic and eukaryotic genomes;
- the synteny and evolution of genomes;
- methods to map single and complex genetic traits;
- methods to go from positions in a genome to a gene of interest;
- methods for analysis of gene function;
- methods to identify genes and ascribe potential functions to their products;
- the applications of genomic information in the fields of medicine, optimisation of nutrition, animal breeding and production, plant breeding and production;
The participants should acquire basic skills in - constructing and interpreting genetic and/or molecular linkage maps;
- searching and interpreting information on genomics in internet-based databases.

Examination:

Students must hand in the output from exercises performed during the practical. The course is completed with a written examination. Results from the exercises and the written exam both count for the final mark (30:70).

Literature:

The contents of the course are available via Blackboard and an accompanying printed manual. The material contains links to relevant websites and links referring to exercises, to Powerpoint presentations or to additional background information in review papers (PDF files). In addition, copied prints of supplementary information will be handed out. A printed study manual is available that summarises the aims and objectives of the course and the characteristics of each chapter.