HNH-31903 Randomised Controlled Trials: Design and Analysis


Studiepunten 3.00

Knowledge clip0
Individual Paper0
Independent study0
E-learning material0
Course coordinator(s)dr. ir. RM Winkels
Lecturer(s)dr. ir. NM de Roos
dr. ir. RM Winkels
Examiner(s)dr. ir. RM Winkels

Language of instruction:


Assumed knowledge on:

HNH-28803 Introduction Analytical Epidemiology and Public Health


Note: This course can not be combined in an individual programme with HNH-24306 Methodology Nutrition Reseach.
This course focuses on the methodological issues in designing an experimental study: how to obtain an appropriate sample size and how to perform statistical analysis of data derived from randomized controlled trials.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- formulate a proper research question to be answered using an RCT;
- evaluate the validity and precision of a parallel arm post-test only, parallel arm pre-test post-test, and cross-over design;
- perform appropriate sample size calculations for different study designs;
- choose and conduct the appropriate method of data analysis of randomized controlled trials, given the study design and type of variables.


Studying knowledge clips, studying e-modules, individual assignment, and individual assignment with peer-review.


Remote proctored written exam (100%) and assignments during the course. Assignments will not be graded, but need to be submitted in time, in order to pass the course. 


Medical Statistics at a Glance, Eight Edition, 2009. Petrie and Sabin. Publisher: John Wiley & Sons, Ltd. Chapters 9, 20, 21, 22, 24, 25.
Fundamentals of clinical trials (Vol. 4), 2010. Friedman, L. M., Furberg, C., DeMets, D. L., Reboussin, D. M., & Granger, C. B. Publisher: Springer. Chapter 6.

Verplicht voor: MNHDLNutritional Epidemiology and Public HealthMSc4DL