HAP-32806 Energy for Life- Molecular Nutritional Physiology of Energy Metabolism


Studiepunten 6.00

Course coordinator(s)dr. S Timmers
Lecturer(s)prof. dr. ir. AH Kersten
prof. dr. ir. J Keijer
dr. ir. EM van Schothorst
dr. VCJ de Boer
dr. S Timmers
dr. W Koopman
dr. C Carmone
X Zhang
Examiner(s)dr. S Timmers
prof. dr. ir. J Keijer

Language of instruction:


Mandatory knowledge:

ZSS06100 Laboratory Safety

Assumed knowledge on:

HAP-30306 Nutritional Physiology 


In this course, we will examine the metabolic regulation of mitochondrial energy metabolism and of substrate metabolism. It will be discussed how you can measure energy metabolism and related physiological functions on the whole-body, tissue and cellular level, and how specific nutrients and compounds affect energy metabolism, including targeting strategies to improve performance and health.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- predict how mitochondria and mitochondrial (dys)function impact on metabolic health at the mechanistic level;
- discriminate between current methods for assessment of energy metabolism;
- elaborate on the concept of metabolic flexibility;
- analyze at a molecular/ mechanistic level the impact of key modifying conditions/ factors, belonging to the domain of nutrition and pharmacy, on energy metabolism;
- analyze and integrate physiological and molecular responses of an organism's energy system to a challenge.


Each week will consist of three lectures of which one will be a guest lecture, a method tutorial/practical and an experimental practical.


The examination contains elements of all parts of the course (lecture slides, articles marked as examination material, practicals and tutorials). All practicals and tutorials are obligatory (attendance list). 
A practical report will be examined (on scientific content), and contributes in total for 25% of the final mark. A written open-question exam will contribute in total for 75% of the final mark.
The minimum mark for the written examination that is needed to successfully complete this course is 5.5. The points acquired for the practical report do not expire, but remain valid until the student has passed the course.


The course has no reader. The course content consists of lectures, experimental practicals and methods practicals/tutorials. The learning material are lecture slides, provided in/with practicals and tutorials, indicated articles and video-clips. Links to review articles with some selected primary research papers provide additional background information and, when indicated, learning material. The information about the practicals//tutorials is available on blackboard. The slides of the lectures will be made available (in pdf format) on blackboard.

Keuze voor: MNHNutrition and HealthMScB: Spec. B - Nutritional Physiology and Health Status4WD
MNHNutrition and HealthMScC: Spec. C - Molecular Nutrition and Toxicology4WD