HAP-31306 Development and Healthy Aging


Studiepunten 6.00

Independent study0
Course coordinator(s)prof. dr. ir. J Keijer
dr. S Grefte
Lecturer(s)dr. S Grefte
prof. dr. ir. J Keijer
dr. BJA Pollux
prof. dr. ir. HFJ Savelkoul
Examiner(s)prof. dr. ir. J Keijer
dr. S Grefte

Language of instruction:


Mandatory knowledge:

ZSS06100 Laboratory Safety

Assumed knowledge on:

EZO-10306 Human and Animal Biology I, HAP20306 Human and Animal Biology II, HAP-10306 Principles of Human Physiology, HAP-21303 Integrated Human Physiology, and CBI-10306 (Introduction in) Cell Biology or equivalent.

Continuation courses:

EZO-30306 Developmental Biology of Animals; EZO-30806 Functional Zoology; HAP-30306 Nutritional Physiology; HAP-30806 Brain Hormones and Metabolism; CBI-30306 Human and Veterinary Immunology; CBI-30806 Immunotechnology; HAP-31806 Molecular Regulation of Health and Disease.


The course highlights three related areas scientifically relevant to development and healthy aging (in other words: aging healthy), corresponding to the expertise of the chair groups involved. We start with an introduction and refreshing previous gained knowledge. Next, the Dutch Famine will be discussed from different angles, which nicely illustrates the interrelationship between development and healthy aging. This is followed by a discussion on embryonic development and early life programming. In the second week we focus on aging healthy by gaining cellular and molecular knowledge about (muscle) mitochondrial functions, metabolic health and energy metabolism in relation to aging. Finally, the third week focusses on immunology and immunomodulation in relation to healthy aging.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- understand how maternal effects and genetic maternal-fetal conflicts change during the evolution of the placenta in live-bearing animals;
- predict how mitochondria and mitochondrial functions impact aging at a mechanistic level;
- explain at a mechanistic level IGF1/Insulin, AMPK and Sirtuin signalling and function in relation to development and age-related changes in (metabolic) health;
- assess how immunological mechanisms underlying aberrant and beneficial immune responses contribute to health in various stages of life;
- integrate current methodology and biological knowledge to design interventions for a functional improvement of muscle, the immune system, and metabolism in human and animal development, .


- lectures;
- group work (case);
- practicals;
- computer learning;
- self study.


- case (2x presentations and 1x written report) (totally 30%);
- written examination (70%).


Reader and handouts of the lectures.
Information on Brightspace.

Keuze voor: MASAnimal SciencesMScE: Spec. E - Molecule, Cell and Organ Functioning3WD
MASAnimal SciencesMScE: Spec. E - Molecule, Cell and Organ Functioning3WD
MASAnimal SciencesMScE: Spec. E - Molecule, Cell and Organ Functioning3WD
MASAnimal SciencesMScB: Spec. B - Nutrition and Metabolism3WD
MASAnimal SciencesMScB: Spec. B - Nutrition and Metabolism3WD
MNHNutrition and HealthMScC: Spec. C - Molecular Nutrition and Toxicology3WD
Keuze voor: WUHAHBSc Minor Healthy Aging in Humans and Model Species3WD