## Vak

Studiepunten 6.00

 Onderwijstype Contacturen Lecture 18 Tutorial 42 Practical 20
 Course coordinator(s) dr. ir. A Rinzema Lecturer(s) dr. G Olivieri dr. ir. A Rinzema Examiner(s) dr. G Olivieri dr. ir. A Rinzema

EN

### Assumed knowledge on:

BPE-21306 Bioreactor Design.

### Continuation courses:

BPE-60312 Bioprocess Design; BPE-80324 Thesis BPE.

### Contents:

Large bioreactors are used for production of many biobased products. As a biotechnologist, you have to find the right combination of production rate, product concentration and product yield on reactants and utilities, in connection with upstream and downstream unit operations.
In this course, we teach you how:
- scale-up affects reactor behavior;
- cell retention affects reactor performance;
- an imbalance between supply rates of several reactants can be utilized to steer metabolism;
- you can use mathematical models for design and operation, taking into account the subjects above.

### Learning outcomes:

After successful completion of this course students are expected to be able to:
- remember the effects of cell retention, biofilms and scale- up on physical reactor behavior;
- understand the strategy for building mathematical models for bioreactors, and for simplifying and solving them;
- apply such models to design reactors and optimize their operation in the framework of a process;
- analyze how design choices and operating conditions affect the outcome of a process;
- create better processes given an optimization criterion.

### Activities:

Lectures, tutorials, computer practical's.

### Examination:

A closed-book written exam consisting of open questions.

Opleiding Fase Specialisatie Periode Keuze voor: MBT Biotechnology MSc D: Spec. D - Process Technology 3WD MFT Food Technology MSc C: Spec. C - Food Fermentation and Biotechnology 3WD MFT Food Technology MSc B: Spec. B - Sustainable Food Process Engineering 3WD