BPE-21306 Bioreactor Design


Studiepunten 6.00

Course coordinator(s)dr. ir. A Rinzema
Lecturer(s)dr. ir. A Rinzema
I Houthoff
Examiner(s)dr. ir. A Rinzema

Language of instruction:


Assumed knowledge on:

BPE-22306 Basic Cell Factory Design.

Continuation courses:

BPE-20806 Separation Process Design;
BPE-36306 Advanced Bioreactor Design.


This course is the third in a series of process engineering courses in the BSc Biotechnology. It applies the design approach taught in BPE-12806 and BPE-22306 to bioreactors limited by sugar supply, oxygen supply or photon supply, and to bioreactors limited by removal of heat or toxic products. Since transfer of material between for example gas and liquid is important in many of these systems, this course also provides a stepping stone to BPE-20806.

Learning outcomes:

After successful completion of this course students are expected to be able to: 
- design reactors with mass transfer between two ideally mixed fluid phases, for continuous, fed-batch, batch operation; 
- design reactors with mass, heat or product transfer between an ideally mixed fluid phase and a fluid phase moving in ideal plug flow, for continuous, fed-batch, batch operation; 
- design photo-bioreactors with mass transfer between two ideally mixed fluid phases; 
- handle various expressions for the intrinsic reaction kinetics for all reactors above; 
- apply judicious simplifications to a reactor design model for all reactors above, to allow analytical solution; 
- analyse differences between reactor types and modes of operation, and exploit these differences for various design goals. 
In the context of this course, design is defined as: 
- the construction of mathematical models based on balances for elements, reactants or products, combined with appropriate equations for conversion and transport kinetics; 
- the use of these models to find allowed or required flow rates, concentrations, conversion rates or vessel volumes; 
Students should be able to complete these design tasks independently and without access to materials used during the course or similar materials from other sources.


- lectures and associated self-study of lecture notes and syllabus;
- supervised exercise classes.


A closed-book exam consisting of open questions about elements from the list above.


Study guide and reader are available on the internet before the start of the course; lecture slides, exercises and answers to exercises are made available during the course.

Verplicht voor: BBTBiotechnologyBSc2AF
Keuze voor: MFTFood TechnologyMScC: Spec. C - Food Fermentation and Biotechnology2AF
MFTFood TechnologyMScB: Spec. B - Sustainable Food Process Engineering2AF