BIP-31806 Advances in Magnetic Resonance

Course

Credits 6.00

Teaching methodContact hours
Lecture24
Tutorial12
Practical36
Course coordinator(s)C Terenzi PhD
Lecturer(s)ir. FJ Vergeldt
prof. dr. JPM van Duynhoven
B van Lagen
C Terenzi PhD
KW Milc
WMJ Franssen
M Mayar
dr. H Van As
dr. MR Serial
Examiner(s)C Terenzi PhD

Language of instruction:

EN

Mandatory knowledge:

ZSS06100 Laboratory Safety

Contents:

The development of molecular sciences for materials, food and health critically depends on comprehensive and non-invasive product characterization. Nuclear magnetic resonance (NMR) is probably the most widely applied analytical method with applications in e.g. analytical chemistry (identification and molecular structure), structural biology (structure, functional dynamics and interactions of large biomolecules; proteomics), solid materials (physical characterization), imaging (visualization and functional analysis of tissues, organs and organisms of humans, animals and plants), metabolomics (quantitative analysis of metabolites), transport processes (characterization of transport in porous (bio)materials with applications in diverse fields like chemical engineering, medicine, food technology, geophysics, biology and ecology).

NMR can be considered special because fundamentally novel scientific discoveries in NMR and MRI have consistently emerged with the development of science. In this course a generalized formalism will be introduced to analyse and understand diverse classes of modern NMR and MRI experiments. The course material will be exemplified by using practical examples of both NMR and MRI from the field of molecular life sciences.

Learning outcomes:

After successful completion of this course students are expected to be able to:

- understand the generalized k space formalism

- perform calculations with spin systems, spin operators, magnetic field gradients and coherence transfer pathways

- understand divers modern NMR and MRI experiments

- understand the effects of relaxation, flow, molecular diffusion, chemical shift and spin-spin couplings

- demonstrate the use of advanced magnetic resonance (NMR and ESR) methods in practical situations

- apply magnetic resonance methods to biomolecules and biological systems.

Activities:

- attend lectures and studying the course material;

- working out of problems and exercises;

- performing magnetic resonance experiments in small groups;

- analysis of experimental results;

- use ICT for analysis and simulations;

- study of cases;

- writing reports.

Examination:

The course will be concluded with a written exam. The required course material for this exam consists of the course materials treated in all lectures, tutorials, and laboratory experiments. The exam has an open-book character and consists of a number of open problems. The laboratory experiments are evaluated on basis of: presence, knowledge, experimental results, working out of the exercises and reports. The final mark is calculated as follows: 70% written exam, 30% laboratory experiments. The bottom mark for both parts is a 5. The final mark can be assessed only after completing all practical courses. Partial results remain valid for a period of 5 years.

Literature:

A syllabus and manual for practical experiments will be available at the beginning of the course.

ProgrammePhaseSpecializationPeriod
Restricted Optional for: MMLMolecular Life SciencesMScC: Spec. C Physical Biology5MO
MMLMolecular Life SciencesMScD: Spec. D Physical Chemistry5MO