MIB-30806 Applied Molecular Microbiology

Course

Credits 6.00

Language of instruction:

English

Assumed knowledge on:

Microbiology & Biochemistry, Microbial Physiology, Biotechnology 1, Cell physiology & Gentechnology.

Continuation courses:

Thesis/Minor/Stage BIC, CBI, GEN, MOB, MIB, VIR.

Contents:

For thousands of years the natural bio-converting capacity of many microorganisms is being exploited by man in a variety of 'classical' biotechnology applications. Over the last 50 years, a dramatic gain of insight in molecular genetics of microorganisms has resulted in the development of the 'modern' biotechnology: the engineering of microorganisms and their enzymes to further enhance the efficiency of specific bio-conversions. The goal of the course Applied Molecular Microbiology is to provide insight in the molecular details of a variety of biotechnological processes, and to give an overview of the currently available set of methods that are being used to optimize specific bioconversions.
The book 'Biology of Microorganisms'(Brock 13th ed.) describes most of the basic knowledge, and it is strongly recommended to use this book during the course. Additional information will be described in the reader Applied Molecular Microbiology. Apart from the lecturers and guest lecturers, the students will participate in 'case studies' in which specific problems are addressed, either in small groups or individually (coordinated by Stan Brouns).

Learning outcomes:

After successful completion of this course students are expected to be able to:
- explain the principles of relevant classical and modern molecular genetics tools;
- select appropriate engineering methods to address specific biotechnology problems;
- analyse molecular genetics reports in the biotechnology literature, and prepare a concise report and/or presentation on a given case.

Activities:

The students work in small groups on a number of cases related to the different theme's of the course.

Examination:

- written examination (75%);
- reports of the cases (25%).

Literature:

Reader Applied Molecular Microbiology and Biology of Microorganisms.
Michael T. Madigan; John M. Martinko; [et.al]. (2014). Brock Biology of Microorganisms. 13 or 14th ed. ISBN 13: 9781292018317.