HNE-27306 Human Pathology

Course

Credits 6.00

Language of instruction:

English

Assumed knowledge on:

HAP-10306 Principles of Human Physiology and CBI-10306 Cell Biology or similar courses.
The student should have knowledge about structure and function of (normal) cells and tssues; basic principles of embryology and physiology of vital organs.

Contents:

In this course, students will study the main processes underlying wound healing, inflammation, cancer, and cardiovascular diseases in humans. To be able to investigate diseased tissues, basic human microscopical anatomy will be introduced first.

Learning outcomes:

After successful completion of this course students are expected to:
- be familiar with structure and function of primary tissue types, and with the functional histology and microscopical structure of the four organ systems that will be studied to demonstrate the various general pathophysiological processes (liver, respiratory tract/esophagus, kidney and cardiovascular system);
- be able to describe relations between the microscopical anatomy and the function(s) of the respective organs or organ systems;
- be able to discuss target identification in disease prevention, diagnostics and therapy;
- be able to explain the causes, mechanisms, manifestations and consequences of cell and tissue damage by means of relevant examples, and will be familiar with the adaptive reactions of the human body, including wound healing;
- understand that inflammation is a universal reaction to tissue damage and can explain the patient's local and systemic symptoms related to inflammation;
- know the underlying pathophysiological processes and the morphological changes in tissues caused by these processes;
- be able to explain the causes, generation, manifestations and consequences of neoplasia (cancer) and cardiovascular diseases;
- be able to discuss target identification in prevention, diagnostics and therapy of these disease processes.

Activities:

- lectures;
- response lectures;
- practical's (virtual microscopy on PC);
- selfstudy in groups.

Examination:

Written exam with closed questions.

Literature:

Rubin E.; Farber JB. Essential Pathology. 3rd ed. Lippincott-Raven, Philadelphia. ISBN: 0781723957.
A course reader will be available at the WUR-shop.