ORC-30806 Structure and Reactivity

Course

Credits 6.00

Language of instruction:

English

Assumed knowledge on:

ORC-11806 Analytical Methods in Organic Chemistry; ORC-20306 Organic Chemistry

Continuation courses:

Research Methods in Organic Chemistry, MSc thesis ORC

Contents:

This course comprises classroom lectures, tutorials and a short literature study, all devoted to the (chemical and biological) reactivity and stereochemistry of organic compounds. After an introduction on basic concepts, a treatise of different types of reactions is given, including nucleophilic substitution, elimination, electrophilic substitution and pericyclic reactions. Next, the structure and reactivity of chiral compounds will be reviewed. Extensive attention will be given to the synthetic routes that are involved in the production of stereochemically pure compounds. The course is concluded with a short treatise of linear free energy relationships and quantitative structure-activity relationships (QSAR).

Learning outcomes:

- be able to understand the structure and chemical and biological (re)activity of organic compounds;
- be able to use reaction mechanisms to explain chemical reactions and reactivity.

Activities:

Studying the theory, solving problems/exercises, making a short literature study.

Examination:

The final mark is based on the result of the written examination (80%) and the literature study (20%). Both parts have to be passed before the final grade can be given. During the exam, the course material may be used ('open book exam').

Literature:

Lecture notes and study guide.