HMI-50306 Host-Microbe Interactomics


Credits 6.00

Teaching methodContact hours
Practical intensively supervised25
Project learning11
Course coordinator(s)prof. dr. J Wells
Lecturer(s)prof. dr. J Wells
prof. dr. ir. PJGM de Wit
Examiner(s)prof. dr. J Wells
prof. dr. ir. PJGM de Wit

Language of instruction:


Continuation courses:

CBI-20306, ENT-30806, NEM-30306, PHP-30306, VIR-30306, ENT-30306, PHP-30806


Viruses, protozoa, bacteria, fungi, omycetes, flatworms, nematodes, mites, ticks and insects pose a constant threat to human and animal health. In this course the molecular biology of the interactions of humans and animals with causal agents of diseases will be addressed, with a focus on bacterial and fungal pathogens. This includes eukaryotic cell signaling in infection, virulence and pathogenesis mechanisms, toxins as pathogenicity factors, evasion of host defense, and the molecular analysis of host-pathogen interactions. This course builds further on the knowledge obtained in the course Basics of Infectious Diseases, their Transmission and Control.

Learning outcomes:

At the end of the course the student is expected to be able to:
- identify the key innate and adaptive defense mechanisms of animals, humans and plants;
- demonstrate understanding of the mechanisms of virulence and pathogenesis for representative bacterial pathogens;
- identify strategies that can be used to control, prevent and treat infectious diseases;
- report on scientific research via an oral presentation; - demonstrate understanding of the experimental approaches used to investigate pathogen biology.


- lectures;
- practicals on the molecular biology of infectious diseases;
- oral presentation on disease mechanisms of an important bacterial pathogen.


Written examination on the contents of the lectures and reader (70%) as well as assessments of the practical report (15%) and oral presentation (15%) .


A course 'reader' will be available.
Additional literature (optional) Wilson, M., McNab R., and Henderson B. (2002) Bacterial Disease Mechanisms: An introduction to Cellular Microbiology.

Compulsory for: WUBIDBSc Minor Biology of Infectious Diseases of Humans and Animals2AF