BPE-21306 Bioreactor Design
Course
Credits 6.00
Teaching method | Contact hours |
Lectures | 12 |
Practical extensively supervised | 60 |
Practical intensively supervised | 25 |
Course coordinator(s) | dr. ir. A Rinzema |
Lecturer(s) | dr. ir. A Rinzema |
ing. EJ van den End | |
S Haemers | |
dr. ir. MH Vermuë | |
Examiner(s) | dr. ir. A Rinzema |
prof. dr. ir. RH Wijffels |
Language of instruction:
English
Assumed knowledge on:
BPE-20806
Continuation courses:
BPE-60312, FPE-31306
Contents:
This course is the third in a series of process engineering courses in the BSc Biotechnology. It applies the systematic design approach taught in BPE-10305 and BPE-20806 to multi-phase (= aerated) bioreactors with homogeneous and inhomogeneous liquid and gas phases. Students set up mass and energy balances for such bioreactors, taking into account simultaneous bioconversion and transport processes. Scale-up effects on mixing and absorption kinetics, and limits imposed by flooding are also considered in the design. Examples of bioreactors discussed in the course are stirred-tank bioreactors, bubble columns and packed beds. In an experiment, a stirred-tank bioreactor is studied.
Learning outcomes:
The student will be able to:
- properly set up and solve element balances in combination with component and energy balances for multiphase bioreactors; in other words: calculate the highest possible production rate or product concentration considering oxygen supply and heat removal capacities;
- choose the appropriate balances and system boundaries for solving a design problem related to these bioreactors;
- properly consider scale-up effects and physical limits in the design; in other words: calculate the effects of the size of the bioreactor on oxygen supply and take into consideration the maximum possible gas and mechanical (mixing) power inputs;
- explain differences between reactor types and exploit them for various design goals; in other words: be able to decide when a stirred-tank reactor should be used, when a bubble column or packed bed should be used, etc.
Activities:
- instruction lectures and associated self-study of lecture notes and syllabus;
- exercises and case studies;
- an experiment, including the required design calculations and report writing;
- written exam.
Examination:
Individual assessment based on marks for the written exam (80%) and the experiment (20%). Both marks must be >5.5.
Literature:
Study guide, syllabus and exercises are available on the internet before the start of the course.
Programme | Phase | Specialization | Period | ||
---|---|---|---|---|---|
Compulsory for: | BBT | Biotechnology | BSc | 5AF | |
Restricted Optional for: | MFT | Food Technology | MSc | H: Sustainable Food Processing | 5AF |
MFT | Food Technology | MSc | A: Food Biotechnology | 5AF | |
MML | Molecular Life Sciences | MSc | E: Environmental Chemistry | 5AF |