NEM-52306 Concepts and Theories of Healthy Aging


Studiepunten 6.00

Practical intensively supervised40
Course coordinator(s)prof. dr. ir. JE Kammenga
Lecturer(s)prof. dr. ir. JE Kammenga
prof. dr. BJ Zwaan
prof. dr. ir. JL van Leeuwen
prof. dr. ir. HFJ Savelkoul
prof. dr. ir. J Keijer
Examiner(s)prof. dr. ir. JE Kammenga
prof. dr. BJ Zwaan
prof. dr. ir. J Keijer

Language of instruction:



Overview of theories and concepts of aging. We will address how species-specific lifespan evolved and why aging is a unique human problem. Attention will also be paid to the question whether senescence and aging can be avoided in organisms and which forces and factors should facilitate this, in particular physical exercise and caloric restriction. We will link the theories with experiments to test the hypotheses of aging theories. The results and emerging genetic, developmental, and physiological mechanisms will be compared across species with a continuous reflection on the role between lifestyle factors. Finally, we will discuss the potential of translational research.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- recall the perspective of theories of aging;
- explain the main evolutionary theories of aging;
- design experiments to test current viewpoints in aging research and translate results from models to pets, and humans


Lectures; case studies; literature reviews; designing experiments; interpretation of results identifying pitfalls.


Grading experimental design, Written exam, Thesis assay.


Seminal papers, recent reviews.

Verplicht voor: WUHAHBSc Minor Healthy Aging in Humans and Model Species1AF