CBI-50806 Immunomodulation by Food and Feed

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Studiepunten 6.00

OnderwijstypeContacturen
Lectures24
Practical intensively supervised36
Project learning36
Course coordinator(s)prof. dr. HJ Wichers
prof. dr. ir. HFJ Savelkoul
Lecturer(s)prof. dr. HJ Wichers
prof. dr. ir. HFJ Savelkoul
prof. dr. RF Witkamp
prof. dr. H Smidt
dr. C Belzer
Examiner(s)prof. dr. HJ Wichers
prof. dr. ir. HFJ Savelkoul

Language of instruction:

English

Assumed knowledge on:

CBI-20306, HNE-10306, ANU-20306, MIB-11306

Continuation courses:

CBI-30306, HNE-39306, ANU-30806, MIB-30806

Contents:

The immune system plays a pivotal part in the maintenance of human and animal health and well-being. Disturbances may lead to over-activity against self-antigens (resulting in auto-immunity), over-activity against harmless environmental antigens (causing allergies), or immune suppression (with impaired resistance against infections and the development of tumors). Immunomodulation offers options to redirect and rebalance the perturbed immune system via food and feed and components that are derived thereof. The interactions between the immune system and food components, food-borne infections and gut microbiota are the central items of this course. The course comprises an overview of underlying mechanisms of immune-related disorders related to disturbed balances in (gut) microbiota and in interaction with selected food components in humans, companion and production animals.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- explain the concept of immunomodulation and its application in the modification and re-directioning of immune-mediated diseases;
- summarize selected food components with defined immunological activity, the mechanisms of action of such compounds, and the tools that are necessary and widely used to assess this activity;
- define and memorize the impact of food components on structure-activity relationship of the gut-associated immune system and the gut microbiota;
- design a systems biological approach for the multiparameter and multilevel analysis of the immunomodulatory effect of (selected) food components on cytokine networks and resulting T-cell mediated activity;
- apply the theoretical and practical knowledge acquired during the course to formulate research questions relevant to an internship or thesis in the field of interactions between food components and food-borne infections with immune functioning and structure-function relationships of the gut microbiota;
- critically evaluate research papers and translate these into a comprehensive review.

Activities:

Attend lectures that are supported by handout lecture material, attend working groups and self-study based on problem oriented education using selected relevant papers. A practical will deal with the tools commonly used to assess the modulatory activity of food components on the immune and microbiota activity.

Examination:

The synthesis of the different aspects of interactions between food components and food-borne infections with immune functioning and structure-function relationships of the gut microbiota will be assessed in a written exam using assay questions (50%). A separate mark will be given for the practical (20%), and also a separate mark will be given for the individual case study report (30%).

Literature:

Study guide, reader, selected literature, practical manual.

MinorPeriode
Verplicht voor: WUMINBSc Minor Microbes Inside2MO