SSB-31312 Toolbox in Systems and Synthetic Biology

Course

Credits 12.00

Teaching methodContact hours
Thesis0
Course coordinator(s)dr. E Saccenti
Lecturer(s)E Asin Garcia
L Garcia Morales
dr. E Saccenti
Examiner(s)dr. M Suarez Diez

Language of instruction:

English

Assumed knowledge on:

SSB-50806 Systems and Synthetic Biology.

Continuation courses:

MSc Thesis.

Contents:

Synthetic Biology is the idea to modify nature such that biological systems exhibit desired properties. It draws on modern experimental techniques of molecular biology but has also a strong engineering component using mathematical modeling to design and analyse biological systems. In Systems Biology one aims to analyse and undertand natural systems while in Synthetic Biology one aims to exploit this knowledge to engineer new functionality. It provides novel possibilities for cellular modification, design of novel or modified networks (pathways) with the aim to get a better understanding of biological principles or for the production of novel proteins or metabolites. This course is aimed to deal with a selection of the following topics.
Desgin and analysis of metabolic models, design and analysis of metabolic pathways, dynamic mathematical models, network analysis, construction and test of synthetic circuits (such as toggle switches, logic gates, optogenetic circuits), construction of biosensor (e.g. to measure redox balance in vivo). Projects can be experimental, computational or a combination thereof. Please contact the course coordinator before registering to know the actual project availability.

Learning outcomes:

After successful completion of this course students are expected to:
- be able to understand the concepts of Systems and Synthetic Biology;
- be able to design, analyze, engineer biological systems;
- be able to be involved in several experiments simultaneously, occasionally in different research groups;
- be able to collect background information independently;
- have experience in performing research in a small group;
- have documented the results of their experiments properly and have presented them written and orally.

Activities:

Experimental or computational project as a member of a team.

Examination:

The final mark will be based on the laboratory skills (40%);
shown during the project, on the quality of the oral presentation (20%);
written report (40%) of the results of the project.

Literature:

Will be provided during the course.

ProgrammePhaseSpecializationPeriod
Restricted Optional for: MBTBiotechnologyMScC: Medical Biotechnology5WD, 6WD