CBI-30306 Human and Veterinary Immunology

Course

Credits 6.00

Teaching methodContact hours
Individual Paper10
Lecture20
Practical40
Independent study0
Course coordinator(s)dr. E Tijhaar
Lecturer(s)dr. M Forlenza
dr. E Tijhaar
Examiner(s)dr. R Tennekes
dr. E Tijhaar

Language of instruction:

EN

Mandatory knowledge:

ZSS06100 Laboratory Safety

Assumed knowledge on:

CBI-10306 Cell Biology; CBI-20306 Cell Biology and Health.

Continuation courses:

Internship or Thesis.

Contents:

Note: This course has a maximum number of participants.
The deadline for registration is one week earlier than usual. See Academic Year:
https://www.wur.nl/en/Education-Programmes/Current-Students/Agenda-Calendar-Academic-Year.htm->Registration for Courses.
The object of the individual is to survive as an individual. To maintain integrity organisms have developed a highly complex and interactive immune system. Although the immune system of vertebrate species is similar, there certainly is more than one method of individual defence that is successful. In fact, the human immune system is just one of many successful mechanisms that operate in the animal world. To reach a level of understanding of the complex system that will allow us to understand why malfunctions such as autoimmunity and immune deficiency develop, we have to consider the system down to its basic components and their functions. Animals, just like humans, suffer from a range of infectious diseases. As veterinary medicine has advanced, prevention of disease has become a priority as healthy food comes from healthy animals. One of the best means of preventing disease is by creating immunity in the animal. This is usually achieved by vaccination. The aim of this course is to provide advanced knowledge on the functioning of the immune system at both, cellular and organ level as well as its evolutionary development. The expertise level is such that it prepares for an immunological Internship (e.g. with a Bio-Medical Group) or a thesis at the Cell Biology and Immunology Group. The (biotechnical) development of vaccines will be dealt with in another course (CBI-30806). Practical's will deal with immunological techniques, (cell isolation, nitric
oxide assay, RT-PCR, ELISA) aiming to understand the host immune response to infection. Practicals also include a study of the histophysiology of blood and immune organs.s.

Learning outcomes:

After successful completion of of this course students are expected to be able to:
- define and memorize the immune defence reactions against pathogens and the basis of the development of deficiency and auto immunity;
- define and memorize the organs, cells and molecules that play a major role in this defence;
- discuss the differences between the mammalian immune system and the immune system of lower vertebrates;
- apply the theoretical knowledge acquired during the course to formulate research questions relevant to an internship or thesis;
- apply the practical knowledge acquired during the course to resolve research questions applicable to an internship or thesis;
- critically evaluate research papers and translate these into a comprehensive personalized review.

Activities:

The course is divided into 3 blocks. Week 1-2 lectures will be on Monday, Wednesday and Friday in the afternoon; Tuesday and Thursday are for self-study, which is highly necessary to keep up with the intensity of the course. In week 3-6, interrupted by one week of practicals, students will be asked to study relevant publications and to compose an individual paper dealing with various aspects of the immune system. Different subjects will be supervised in groups of 10 students approximately, but it are individual assignments. The report is due on 5 p.m. of Friday of week 6.
In week 5
or 6, one week of practicals will be followed that deal with immunological techniques (cell isolation, nitric oxide/arginase assay, RT-PCR, ELISA, and data analysis of cytokine assays) aiming to understand the host immune response to infection. Practicals also include a study of the histophysiology of immune organs.

Examination:

- individual paper covering the literature assignment. The final score accounts for 30% of the final mark;
-
Following the practicals is obliged, but the practicals will not be marked.
- exam with 60 multiple choice questions. The final score accounts for 70% of the final mark;
- for the report, as well as the final pc-based exam a minimum of 5.0 needs to be scored.

Literature:

Abbas, K.A,; Lichtman, H.H.; Pillai, S. (2011). Cellular and Molecular Immunology. 9th ed. Saunders-Elsevier. ISBN 978-0-323-47978-3. For sale at the WUR-shop.
Manual for the practical course and review articles for the literature assignment will be provided during the course.

ProgrammePhaseSpecializationPeriod
Restricted Optional for: MBIBiologyMScC: Spec. C - Health and Disease1AF
MASAnimal SciencesMScE: Spec. E - Molecule, Cell and Organ Functioning1AF
MASAnimal SciencesMScB: Spec. B - Nutrition and Metabolism1AF
MNHNutrition and HealthMScC: Spec. C - Molecular Nutrition and Toxicology1AF