BPE-21306 Bioreactor Design

Course

Credits 6.00

Teaching methodContact hours
Lecture20
Tutorial48
Practical20
Course coordinator(s)dr. ir. A Rinzema
Lecturer(s)dr. ir. A Rinzema
dr. ir. MH Vermuë
I Houthoff
Examiner(s)dr. ir. MH Vermuë
dr. ir. A Rinzema

Language of instruction:

English

Assumed knowledge on:

BPE-22306 Basic Cell Factory Design.

Continuation courses:

BPE-20806 Separatoin process design; BPE-36306 Advanced Bioreactor design 

Contents:

This course is the third in a series of process engineering courses in the BSc Biotechnology. It applies the design approach taught in BPE-12806 and BPE-22306 to bioreactors limited by sugar supply, oxygen supply or photon supply, and to bioreactors limited by removal of heat or toxic products. Since transfer of material between for example gas and liquid is important in many of these systems, this course also provides a stepping stone to BPE-20806.

Learning outcomes:

After successful completion of this course students are expected to be able to: 
- design reactors with mass transfer between two ideally mixed fluid phases, for continuous, fed-batch, batch operation; 
- design reactors with mass, heat or product transfer between an ideally mixed fluid phase and a fluid phase moving in ideal plugflow, for continuous, fed-batch, batch operation; 
- design photo-bioreactors with mass transfer between two ideally mixed fluid phases; 
- handle various expressions for the intrinsic reaction kinetics for all reactors above; 
- apply judicious simplifications to a reactor design model for all reactors above, to allow analytical solution; 
- analyse differences between reactor types and modes of operation, and exploit these differences for various design goals. 

In the context of this course, design is defined as: 
- the construction of mathematical models based on balances for elements, reactants or products, combined with appropriate equations for conversion and transport kinetics; 
- the use of these models to find allowed or required flow rates, concentrations, conversion rates or vessel volumes; 
Students should be able to complete these design tasks independently and without access to materials used during the course or similar materials from other sources.

Activities:

- lectures and associated self-study of lecture notes and syllabus;
- supervised exercise classes.

Examination:

A closed-book exam consisting of open questions about elements from the list above.

Literature:

Study guide and reader are available on the internet before the start of the course; lecture slides, exercises and answers to exercises are made available during the course.

ProgrammePhaseSpecializationPeriod
Compulsory for: BBTBiotechnologyBSc2AF
Restricted Optional for: MFTFood TechnologyMScH: Sustainable Food Process Engineering2AF
MFTFood TechnologyMScA: Food Biotechnology and Biorefining2AF