BNT-53303 Advanced Inorganic Chemistry

Course

Credits 3.00

Teaching methodContact hours
Lecture8
Tutorial12
Practical28
Course coordinator(s)prof. dr. AH Velders
Lecturer(s)prof. dr. AH Velders
dr. A Bunschoten
prof. dr. JH Bitter
Examiner(s)prof. dr. AH Velders

Language of instruction:

EN

Assumed knowledge on:

BioInorganic Chemistry


Continuation courses:

MSc thesis BioNanotechnology

Contents:

This course deals with inorganic chemistry, discussing the presence and role of inorganic elements in biological systems and in novel nanomaterials. Focus is on d-block elements in various oxidation states and the molecular structure of corresponding coordination complexes considering variations in ligands and geometries. The electron configuration and spectroscopic properties of lighter and heavier (d- & and f-) metal complexes are evaluated with Crystal Field and Ligand Field theory as well as spin-orbit coupling aspects. Various Optical (Luminescence) and Magnetic Resonance spectroscopy techniques will be introduced (ESR, NMR and MRI) to evaluate the dynamics, structural properties and function of metal complexes, including catalytic aspects. Special focus ison the synthesis and characterization of nanomaterials, in particular nanoparticles. Homo- and heteronuclear NMR techniques will be taught with focus on nuclear spin-spin as well as electron spin-nuclear spin interactions. Attention is paid to metal-ligand interactions in metalloenzymes and the structural and functional aspects thereof. Special attention is for the application of paramagnetic metal complexes. The ligand dynamics is put in perspective of field of medicinal inorganic chemistry as well as homogneous and heterogeneous catalysis is addressed. During laboratory classes diamagnetic and paramagnetic metal coordination complexes and nanoparticles will be synthesized and analyzed, linking MO theory to the  physical-chemical  properties of metal compounds. It further provides training in the use of magnetic resonance and optical spectroscopic equipment, the interpretation of spectra resulting in the deduction of molecular structure and geometry.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- understand the importance of inorganic chemistry (in particular d- and f-block elements);
- demonstrate understanding of Crystal-Field, Ligand-Field theory and spin-orbit coupling;
- relate (photo)physical and magnetic properties of metal complexes and nanoparticles;
- assess heteronuclear 1D and 2D NMR spectroscopy in characterization of metal complexes;
- assess coordination chemistry to topics in nanomaterials and catalysis;
- synthesize heavier transition metal coordination complexes and nanoparticles and characterize them by 1D and 2D MR and optical spectroscopic techniques

Activities:

Lectures and self-study, tutorials, laboratory experiments, reporting.

Examination:

Written examination with open questions (50%), plus report on laboratory classes (50%).

Final mark is composed if both parts were marked with a 5.0 or higher and the weighted average should be 5.5 or higher to pass.

Literature:

Weller, Overton, Rourke en Armstrong, Inorganic Chemistry 7th edition, Oxford Univ. Press.