ABG-30306 Genomics


Credits 6.00

Teaching methodContact hours
Course coordinator(s)dr. O Madsen
Lecturer(s)prof. dr. ME Schranz
dr. ir. HJ Megens
dr. O Madsen
dr. JAL van Kan
prof. dr. MAM Groenen
MFL Derks
Examiner(s)dr. O Madsen
prof. dr. MAM Groenen

Language of instruction:


Assumed knowledge on:

Basic knowledge on molecular biology and genetics, such as given in GEN-11806 Fundamentals in Genetics, or courses such as BIC-10306 Practical Biological Chemistry or MOB-20306 Gene Technology. 


Note: This course has a maximum number of participants. The deadline for registration is one week earlier than usual.
See Academic Year.(http://www.wur.nl/en/Education-Programmes/Current-Students/Agenda-Calendar-Academic-Year.htm) -> Registration for Courses.
The course discusses the structure and function of genomes of organisms from all kingdoms. The topics that are treated cover:
- chromosome structure and topology;
- genome sequencing, genome assembly and functional annotation;
- whole genome sequence analysis; genome synteny and evolution;
- transcriptome analysis by RNA-seq; protein-protein interactions and proteomics; epigenomics
- functional genome analysis;
- variation in genomes.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- retrieve and describe information from genomic databases
- describe genome analysis strategies related to genome assembly, annotation, and functional genomics
- describe and explain organization, function and evolution of genomes
- contrast features of genomes of different domains of life, and compare genomes of different species.
- apply and assess tools for genome analysis.
- interpret complex data and analysis results derived from complex biological systems.
- judge the merits of results and interpretations based on known strengths and weaknesses of data sources and analysis strategies.​
- integrate results obtained from literature/research project


The final grade is based on a written examination and the assessment of a literature/research project during the last two weeks of the course.


The contents of the computer exercises are available in Brightspace. Additional material in Brightspace consists of links to relevant websites, to the Powerpoint presentations of the lectures and to further background information in review papers. Literature for the research/literature project is accessible from literature databases and journal home pages.

Restricted Optional for: MBIBiologyMScA: Spec. A - Cell Biology and Molecular Interactions2AF, 5AF
MBTBiotechnologyMScC: Spec. C - Medical Biotechnology5AF
MBTBiotechnologyMScB: Spec. B - Food Biotechnology2AF
MBTBiotechnologyMScA: Spec. A - Cellular/Molecular Biotechnology2AF, 5AF
MASAnimal SciencesMScE: Spec. E - Molecule, Cell and Organ Functioning2AF
MASAnimal SciencesMScA: Spec. A - Genetics and Biodiversity2AF
MPSPlant SciencesMScD: Spec. D - Plant Breeding and Genetic Resources2AF, 5AF
MPBPlant BiotechnologyMScA: Spec. A - Functional Plant Genomics2AF, 5AF
MPBPlant BiotechnologyMScA: Spec. A - Functional Plant Genomics2AF, 5AF
MPBPlant BiotechnologyMScC: Spec. C - Molecular Plant Breeding and Pathology2AF, 5AF
MBFBioinformaticsMSc2AF, 5AF
Compulsory for: WUEPSBSc Minor Experimental Plant Sciences5AF
WUPBTBSc Minor Plant Biotechnology2AF