ORC-31303 Research Methods in Organic Chemistry

Course

Credits 3.00

Teaching methodContact hours
Practical72
Course coordinator(s)dr. ir. M Smulders
Lecturer(s)dr. ir. M Smulders
Examiner(s)dr. ir. M Smulders

Language of instruction:

EN

Mandatory knowledge:

ZSS06100 Laboratory Safety

Assumed knowledge on:

ORC-20306 Bio-organic Chemistry and ORC-11806 Analytical methods in Organic Chemistry.

Contents:

This practical course is aimed to introduce students to modern research methods in organic chemistry. A combination of advanced experimental techniques and methods in organic chemistry will be covered during the course: e.g. multistep syntheses, reactions under inert conditions, azeotropic distillation, dynamic-covalent chemistry reactions, chromatography, spectroscopy. The subjects are closely related to research projects that are currently under investigation at the Laboratory of Organic Chemistry. The course is meant for students that already have ample practical experience in organic synthesis.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- perform, set up and monitor advanced organic chemistry experiments in a safe way using conditions like low temperatures (-78°C), exclusion of air and moisture, or use of highly reactive reagents;
- obtain the pure reaction product(s) by using appropriate isolation and purification techniques like extraction, chromatography and/or recrystallization;
- identify the structure of the product(s) by recording and interpreting relevant spectra and determining and comparing its physical properties;
- explain the experimental approach and outcome of reactions by describing and explaining the reaction mechanism and consulting literature sources;
- present experimental results and theory in a written report.

Activities:

After successful completion of this course students are expected to be able to:
- set up, perform and work out advanced organic chemistry experiments and measurements;
- study relevant literature;
- write a report about the conducted research.

Examination:

- the final mark is determined by the practical performance (33%);
- the quality of the report (67%).
The minimum mark for each part is 5.50.

ProgrammePhaseSpecializationPeriod
Restricted Optional for: MMLMolecular Life SciencesMSc3MO