TOX-20303 General Toxicology

Course

Credits 3.00

Teaching methodContact hours
Lecture18
Practical20
Course coordinator(s)dr. ir. H Bouwmeester
Lecturer(s)dr. ir. NW van den Brink
prof. dr. ir. IMCM Rietjens
dr. ir. H Bouwmeester
Examiner(s)dr. ir. H Bouwmeester

Language of instruction:

English

Continuation courses:

TOX-30306 Food Toxicology; TOX-30806 Environmental Toxicology

Contents:

Note: This course can not be combined in an individual programme with FHM-22806 Food Hazards.

Introductory course on basic principles in toxicology, organ-specific toxic effects and risk assessment.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- summarize important generalized toxicological (biochemical) mechanisms underlying toxic responses following exposure to toxic chemicals;
- interpret the consequences of physiological processes on toxic responses in the human body;
- apply some important mechanisms (modes of action) of toxic chemicals that underlie the adverse effects observed to important toxic chemicals in food and the environment;
- argue which approaches (in the field of alternative integrated testing strategies) are needed to replace the animal testing in the field of toxicological safety or risk assessment of chemicals;
- recall what type of data is required by regulatory bodies for the safety assessment of chemicals;
- design and execute a comprehensive toxicological concentration-response experiment and critically discus the results;
- create an experimental approach to assess toxic responses that are relevant for human risk assessment;
- apply the basic principles of risk assessment of chemicals in food and the environment.

Activities:

Lectures based on syllabus and Power-point presentations.

A practical course to put the essentials of toxicological (in vitro) experiments into practice.

Examination:

Exam with closed questions on the theory.

Presenting the outcome and the interpretation thereof, of the practical to students (and supervisors)

Literature:

Syllabus.

ProgrammePhaseSpecializationPeriod
Compulsory for: BVGNutrition and HealthBSc1MO
Restricted Optional for: BBIBiologyBScC: Human and Animal Health Biology5MO
MinorPeriod
Restricted Optional for: WUBNTBSc Minor Bionanotechnology1MO
WUCHMBSc Minor Chemical Sciences1MO