TOX-20303 General Toxicology


Credits 3.00

Teaching methodContact hours
Course coordinator(s)dr. ir. H Bouwmeester
Lecturer(s)dr. ir. NW van den Brink
prof. dr. ir. IMCM Rietjens
dr. ir. H Bouwmeester
Examiner(s)dr. ir. H Bouwmeester

Language of instruction:


Continuation courses:

TOX-30306 Food Toxicology; TOX-30806 Environmental Toxicology


Note: This course can not be combined in an individual programme with FHM-22806 Food Hazards.

Introductory course on basic principles in toxicology, organ-specific toxic effects and risk assessment.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- summarize important generalized toxicological (biochemical) mechanisms underlying toxic responses following exposure to toxic chemicals;
- interpret the consequences of physiological processes on toxic responses in the human body;
- apply some important mechanisms (modes of action) of toxic chemicals that underlie the adverse effects observed to important toxic chemicals in food and the environment;
- argue which approaches (in the field of alternative integrated testing strategies) are needed to replace the animal testing in the field of toxicological safety or risk assessment of chemicals;
- recall what type of data is required by regulatory bodies for the safety assessment of chemicals;
- design and execute a comprehensive toxicological concentration-response experiment and critically discus the results;
- create an experimental approach to assess toxic responses that are relevant for human risk assessment;
- apply the basic principles of risk assessment of chemicals in food and the environment.


Lectures based on syllabus and Power-point presentations.

A practical course to put the essentials of toxicological (in vitro) experiments into practice.


Exam with closed questions on the theory.

Presenting the outcome and the interpretation thereof, of the practical to students (and supervisors)



Compulsory for: BVGNutrition and HealthBSc1MO
Restricted Optional for: BBIBiologyBScC: Human and Animal Health Biology5MO
Restricted Optional for: WUBNTBSc Minor Bionanotechnology1MO
WUCHMBSc Minor Chemical Sciences1MO