NEM-52306 Concepts and Theories of Healthy Aging

Course

Credits 6.00

Teaching methodContact hours
Lecture18
Tutorial21
Practical40
Independent study0
Course coordinator(s)prof. dr. ir. JE Kammenga
Lecturer(s)CC van Schaik
prof. dr. ir. HFJ Savelkoul
prof. dr. ir. J Keijer
I van der Stelt, MSc
prof. dr. BJ Zwaan
JAG Riksen
prof. dr. ir. JE Kammenga
ing. J Zandveld
Examiner(s)prof. dr. ir. JE Kammenga

Language of instruction:

English

Contents:

Overview of theories and concepts of aging. We will address how species-specific lifespan evolved and why aging is a unique human problem. Attention will also be paid to the question whether senescence and aging can be avoided in organisms and which forces and factors should facilitate this, in particular physical exercise and caloric restriction. We will link the theories with experiments to test the hypotheses of aging theories. The results and emerging genetic, developmental, and physiological mechanisms will be compared across species with a continuous reflection on the role between lifestyle factors. Finally, we will discuss the potential of translational research.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- recall and explain the genetic and evolutionary theories of human aging;
- explain and apply genetic and physiological pathways underlying longevity in model species and humans;
- design and evaluate experiments to test current viewpoints in aging research and translate results from models to pets, and humans.

Activities:

- lectures;
- case studies;
- conducting experiments to understand the mechanisms underlying ageing;

Examination:

- written test with open questions (60%);
- three interim reports on practical assignments (40%).
The minimum mark for the written test is a 5, for each of the interim reports a minimum mark of 5.5 is required.

Literature:

- seminal papers;
- recent reviews.

MinorPeriod
Compulsory for: WUHAHBSc Minor Healthy Aging in Humans and Model Species1AF