HAP-32806 Energy for Life- Molecular Nutritional Physiology of Energy Metabolism


Credits 6.00

Teaching methodContact hours
Course coordinator(s)dr. S Timmers
Lecturer(s)prof. dr. ir. J Keijer
prof. dr. ir. AH Kersten
dr. ir. EM van Schothorst
dr. VCJ de Boer
dr. W Koopman
X Zhang
dr. C Carmone
dr. S Timmers
Examiner(s)prof. dr. ir. J Keijer
dr. S Timmers

Language of instruction:


Assumed knowledge on:

Nutritional Physiology HAP-30306


In this course, we will examine the metabolic regulation of mitochondrial energy metabolism and of substrate metabolism. It will be discussed how you can measure energy metabolism and related physiological functions on the whole-body, tissue and cellular level, and how specific nutrients and compounds affect energy metabolism, including targeting strategies to improve performance and health.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- predict how mitochondria and mitochondrial functions impact on metabolic health at a mechanistic level;
- mechanistically explain the (molecular) physiological response to fasting;
- mechanistically explain the functional role of B-vitamins in energy metabolism;
- know and be able to explain current methods for assessment of energy metabolism;
- integrate methods and biological knowledge to study effects of nutrition on energy and substrate metabolism [related to literature, method tutorials and practicals];
- analyse physiological and molecular responses of cells related to energy metabolism (related to experimental practical).


Each week will consist of three lectures of which one will be a guest lecture, a method tutorial/practical and an experimental practical.


The examination contains elements of all parts of the course (lecture slides, articles marked as examination material, practicals and tutorials). All practicals and tutorials are obligatory (attendance list). 
A practical report will be examined (on scientific content), and contributes in total for 25% of the final mark. A written open-question exam will contribute in total for 25% of the final mark.
The minimum mark for the written examination that is needed to successfully complete this course is 5.5.


The course has no reader. The course content consists of lectures, experimental practicals and methods practicals/tutorials. The learning material are lecture slides, provided in/with practicals and tutorials, indicated articles and video-clips. Links to review articles with some selected primary research papers provide additional background information and, when indicated, learning material. The information about the practicals//tutorials is available on blackboard. The slides of the lectures will be made available (in pdf format) on blackboard.

Restricted Optional for: MNHNutrition and HealthMScC: Molecular Nutrition and Toxicology4WD
MNHNutrition and HealthMScB: Nutritional Physiology and Health Status4WD