ABG-30306 Genomics

Course

Credits 6.00

Teaching methodContact hours
Lecture16
Tutorial14
Practical76
Course coordinator(s)dr. ir. HJ Megens
dr. O Madsen
Lecturer(s)prof. dr. MAM Groenen
prof. dr. ir. FPM Govers
dr. JAL van Kan
dr. ir. P van Baarlen
dr. ir. HJ Megens
dr. O Madsen
Examiner(s)dr. ir. HJ Megens
dr. O Madsen
dr. JAL van Kan

Language of instruction:

English

Assumed knowledge on:

Basic knowledge on molecular biology and genetics, such as given in GEN-11806 Fundamentals in Genetics, or courses such as BIC-10306 Practical Biological Chemistry or MOB-20306 Gene Technology. 

Contents:

Note: This course has a maximum number of participants. The deadline for registration is one week earlier than usual.
See Academic Year.(http://www.wur.nl/en/Education-Programmes/Current-Students/Agenda-Calendar-Academic-Year.htm) -> Registration for Courses.

The course discusses the structure and function of genomes of living organisms from all kingdoms, with emphasis on Eukaryote genomes. The topics that are treated cover:

- Introduction to Genomics;

- Genetic and Physical Maps;

- Genome Sequencing and Annotation;

- Comparative Genomics;

- Genome Synteny and Evolution;

- Eukaryote Genome Architecure;

- Transcriptomics and Epigenomics;

- Metagenomics;

- Proteomics;

- Variation in Genomes;

- Functional Genomics.


Learning outcomes:

After successful completion of this course students are expected to be able to:
- retrieve and describe information from genomic databases;
- describe genome analysis strategies related to genome assembly, annotation, and functional genomics;
- describe and explain organization, function and evolution of genomes;
- contrast features of genomes of different domains of life, and compare genomes of different species;
- apply and assess tools for genome analysis;
- interpret complex data and analysis results derived from complex biological systems;
- judge the merits of results and interpretations based on known strengths and weaknesses of data sources and analysis strategies.

Examination:

The examination is based on a written test (examination) with open questions and the active participation during contact hours (exercises during the practical). Results from the exercises and the written test both count for the final mark (20:80).

Literature:

The contents of the computer exercises are available in Brightspace. Additional material in Brightspace consists of links to relevant websites, to the Powerpoint presentations of the lectures and to further background information in review papers.

ProgrammePhaseSpecializationPeriod
Restricted Optional for: MBIBiologyMScA: Cell and Molecular Biology2AF, 5AF
MBTBiotechnologyMScC: Medical Biotechnology5AF
MBTBiotechnologyMScB: Food Biotechnology2AF
MBTBiotechnologyMScA: Cellular/Molecular Biotechnology2AF, 5AF
MASAnimal SciencesMScE: Molecule, Cell and Organ Functioning2AF
MASAnimal SciencesMScA: Genetics and Biodiversity2AF
MPSPlant SciencesMScD: Plant Breeding and Genetic Resources2AF, 5AF
MPBPlant BiotechnologyMScA: Functional Plant Genomics2AF, 5AF
MPBPlant BiotechnologyMScA: Functional Plant Genomics2AF, 5AF
MPBPlant BiotechnologyMScC: Molecular Plant Breeding and Pathology2AF, 5AF
MBFBioinformaticsMSc2AF, 5AF
MinorPeriod
Compulsory for: WUEPSBSc Minor Experimental Plant Sciences5AF
WUPBTBSc Minor Plant Biotechnology2AF