HNE-31903 Randomised Controlled Trials: design and analysis (DL)


Credits 3.00

Teaching methodContact hours
Individual Paper
Independent study
Distance Knowledge clip
Distance Tutorial
Distance E-learning material
Course coordinator(s)dr. ir. NM de Roos
Lecturer(s)dr. ir. NM de Roos
Examiner(s)dr. ir. NM de Roos

Language of instruction:


Assumed knowledge on:

DL-introduction in analytical epidemiology; DL-integration of evidence 1

Continuation courses:

The DL-MSc-specializations have a fixed schedule during the pilot-phase


Note: this course is NOT taught in the 17/18 academic year.
Note: This course has a maximum number of participants. The deadline for registration is one week earlier than usual. See Academic Year.( -> Registration for Courses.
Note: The period mentioned below is the period in which this course starts. For the exact academic weeks see the courseplanning on

This course focuses on the methodological issues in designing an experimental study: how to obtain an appropriate sample size and how to perform statistical analysis of data derived from randomized controlled trials.

Learning outcomes:

After successful completion of this course students are expected to be able to: - formulate a good research question;
- evaluate the validity and precision of a parallel arm post-test only, parallel arm pre-test post-test, and cross-over design;
- perform appropriate sample size calculations for different study designs;
- choose and conduct the appropriate method of data analysis of randomized controlled trials, given the study design and type of variables.


Studying knowledge clips, studying e-modules, individual assignment, and individual assignment with peer-review.


Remote proctored written exam (70%), Assignments during the course (30%). Both need a minimum mark of 5.5 to pass the course.


Petrie & Sabin, Medical statistics at a glance, chapters 9, 13, 20, 21, 22, 24, 41.

Compulsory for: MNHNutrition and HealthMScE: Nutritional Epidemiology and Public Health5DL