HNE-30403 Integration of Evidence I (DL)


Credits 3.00

Teaching methodContact hours
Individual Paper
Independent study
Distance Knowledge clip
Distance Tutorial
Distance group work
Distance E-learning material
Course coordinator(s)dr. ir. MC Busstra
Lecturer(s)dr. ir. MC Busstra
prof. dr. ir. P van 't Veer
dr. ir. A Melse-Boonstra
Examiner(s)dr. ir. MC Busstra

Language of instruction:


Assumed knowledge on:

DL courses 'Introduction to Descriptive Epidemiology' and 'Introduction to Analytical Epidemiology'

Continuation courses:

The DL-MSc-specializations have a fixed schedule during the pilot-phase


Note: This course has a maximum number of participants. The deadline for registration is one week earlier than usual. See Academic Year.( -> Registration for Courses.
Note: The period mentioned below is the period in which this course starts. For the exact academic weeks see the courseplanning on

This course focusses on integrating and judging the strength of scientific evidence for a proposed causal relation between a certain (nutritional) exposure and a health outcome.
We take the 'evidence pyramid' as a starting point. The top of the evidence pyramid, the RCT, is discussed in more detail as a 'gold standard' research method. This gives a solid basis to contrast other research approaches and discuss the potential biases. In addition, you study basic statistical analyses methods to quantify intake-health associations in observational studies, as these are the associations that will be judged for their strength of evidence.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- discuss strengths and limitations of observational studies, human intervention studies and animal or cell line studies;
- explain under which circumstances a RCT can/cannot be considered as a gold standard research approach;
- be able to quantify intake-health associations based on results of observational studies.


E-modules, knowledge clips, online group discussion & individual assignment.


- final exam: remote proctored written exam with closed questions (60%);
- group assignment: 'discuss evidence for a proposed dietary intake and health outcome' (40%);
Both components need a minimum mark of 5.5 to pass.


Petrie & Sabin, Medical statistics at a glance, selection of chapters)
Webb & Bain, Essential Epidemiology, 2nd ed, Ch 10
MJ. Gibney et al, Public health nutrition, 2004. Ch 11

Compulsory for: MNHNutrition and HealthMScE: Nutritional Epidemiology and Public Health6DL