ABG-30306 Genomics


Credits 6.00

Teaching methodContact hours
Course coordinator(s)dr. ir. HJ Megens
dr. O Madsen
Lecturer(s)prof. dr. ir. FPM Govers
dr. M Seidl
dr. O Madsen
dr. ir. P van Baarlen
dr. ir. HJ Megens
dr. JAL van Kan
Examiner(s)prof. dr. MAM Groenen
dr. JAL van Kan

Language of instruction:


Assumed knowledge on:

Basic knowledge molecular biology and genetics, such as given in the courses BIC-10306 Practical Biological Chemistry and MOB-20306 Gene Technology.


Note: This course has a maximum number of participants. The deadline for registration is one week earlier than usual. See Academic Year.(http://www.wur.nl/en/Education-Programmes/Current-Students/Agenda-Calendar-Academic-Year.htm) -> Registration for Courses.

The course discusses the structure and function of genomes of living organisms from all kingdoms. The topics that are treated cover:
- molecular markers;
- linkage maps;
- fluorescent in situ hybridization;
- chromosome structure and topology;
- whole genome sequence analysis;
- whole genome comparison;
- genome synteny and evolution;
- expression analysis by micro-array techniques;
- proteomics;
- functional genome analysis by random and targeted mutagenesis.

Learning outcomes:

After successful completion of this course students are expected to be able to:
- find and retrieve genomic information using web based genome browsers and databases;
- recall and use the tools used for the development of genetic, physical and sequence maps of prokaryotic and eukaryotic genomes;
- recall the relations between these different maps and the specific application of the different maps in genome mapping;
- use comparative mapping tools, and in particular be able to explain the concept of genome synteny and orthologous and parologous relationships between genes;
- use methods to identify genes and ascribe potential functions to their products and apply the concept of gene ontology;
- recognize the incompleteness of the available genomic data in databases and that the data is being generated and updated almost on a daily basis;
- use genomic information to deduce information on the organization, functioning and evolution of microbes, plants and animals;
- assess the methods and the results for mapping monogenic and complex genetic traits in the fields of medicine, nutrition, animal breeding and plant breeding.


The examination is based on a written test (examination) with open questions and the active participation during contact hours (exercises during the practical). Results from the exercises and the written test both count for the final mark (20:80).


The contents of the computer exercises are available via Blackboard. Additional material on Blackboard consists of links to relevant websites, to the Powerpoint presentations of the lectures and to further background information in review papers (PDF files).

Restricted Optional for: MBIBiologyMScH: Molecular Development and Gene Regulation2AF, 5AF
MBTBiotechnologyMScA: Cellular/Molecular Biotechnology2AF, 5AF
MBTBiotechnologyMScB: Food Biotechnology2AF
MBTBiotechnologyMScC: Medical Biotechnology5AF
MASAnimal SciencesMScA: Genetics and Biodiversity2AF
MASAnimal SciencesMScE: Molecule, Cell and Organ Functioning2AF
MPSPlant SciencesMScD: Plant Breeding and Genetic Resources2AF, 5AF
MPBPlant BiotechnologyMScA: Functional Plant Genomics2AF, 5AF
MPBPlant BiotechnologyMScA: Functional Plant Genomics2AF, 5AF
MPBPlant BiotechnologyMScC: Molecular Plant Breeding and Pathology2AF, 5AF
MBFBioinformaticsMSc2AF, 5AF
Compulsory for: WUEPSBSc Minor Experimental Plant Sciences5AF
WUPBTBSc Minor Plant Biotechnology2AF