BPE-12806 Bioprocess Engineering Basics BT


Credits 6.00

Teaching methodContact hours
Course coordinator(s)dr. ir. AJB van Boxtel
dr. ir. MH Vermuë
Lecturer(s)dr. ir. PP Lamers
T Haasterecht
dr. ir. AJB van Boxtel
dr. ir. MH Vermuë
dr. ir. DE Martens
KJM Mulders
Examiner(s)dr. ir. AJB van Boxtel
dr. ir. MH Vermuë
dr. ir. DE Martens

Language of instruction:


Assumed knowledge on:

MAT-15003 Mathematics 3.

Continuation courses:

BPE-20806 Process Engineering.


This course is the first in a series of process engineering courses. It introduces systematic design of production processes based on element, component and energy balances. These balances are used to design various systems, ranging from micro-organisms or plants, via equipment for conversion or separation, to a complete biotechnological factory or agricultural production system. The emphasis in this course is on the analysis and solving relatively simple design problems; optimization of the design and analysis of more complex problems are taught in later courses. An equilibrium approach will be used to evaluate individual separation processes and an entire process design. The course illustrates how process engineers can contribute to the development of sustainable production processes by analysing process behaviour.

Learning outcomes:

The student will be able to:
- properly set up element balances, component balances and energy balances for various systems relevant to biotechnology and agrotechnology; this means that the student can formulate mathematical expressions for accumulation, convective transport and (bio)chemical conversion rates required in a balance;
- choose appropriate balances for design problems;
- choose appropriate system boundaries for these balances;
- determine the number of (balance) equations required to solve design questions;
- use phase equilibria in balances for individual separation processes to calculate minimal required flow rates or maximal possible concentrations in product streams;
- use phase equilibria in balances to evaluate the feasibility of an entire process design;
- use given conversion rates or simple kinetic models in balances for conversion processes;
- calculate required size of equipment, required flow rates or final temperature or concentrations in production streams.


- instruction lectures;
- solving of example problems;
- make assignments;
- a case-study;
- writing a short design report;
- self study using lecture notes;
- written exam.


Individual assessment based on the case-study report (25%) and written exam (75%).
Both marks must be equal or more then 5.5. Active participation in working classes is mandatory.


Study guide and lecture notes are available on the first day of the course.

Compulsory for: BBTBiotechnologyBSc6MO
Restricted Optional for: BLSBachelor Orientation year Life SciencesBSc6